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KMID : 0829220140380050267
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Korean Journal of Oral and Maxillofacial Pathology
2014 Volume.38 No. 5 p.267 ~ p.272
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Anticancer Effect of Vitamin K2 in MC3 Mucoepidermoid Carcinoma Cells
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장분실:Jang Boon-sil
오세준:Oh Se-Jun/신지애:Shin Ji-Ae/조남표:Cho Nam-Pyo/조성대:Cho Sung-Dae
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Abstract
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Background. Vitamin K (VK) is a fat-soluble vitamin and is known to have anticancer activity in various cancer cell lines. However, there is no report on the anticancer effect of VK2 in mucoepidermoid carcinoma cells. Methods. The effects of VK2 on anti-proliferative and apoptotic activity were recognized by the trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole (DAPI) staining and Western blot analysis. Results. The results showed that VK2 decreased cell viability and induced apoptotic programmed cell death in MC3 cells evidenced by the cleavages of caspase3 and PARP. VK2 treatment clearly increased Bak and truncated Bid (t-Bid) compared with the control treatment whereas it did not alter other Bcl-2 family members. Conclusions. Overall, our results suggest that VK2 can be a good apoptotic inducer accompanied by the increase in Bak and Bid protein. VK2 may be a potent target of anticancer drug candidate for the treatment of oral cancer.
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KEYWORD
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Vitamin K2, Apoptosis, Bak, Bid, Mucoepidermoid carcinoma cell
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